By Nukkad Mall · 8/20/2026

If your doctor has prescribed O2 Tablet and you're trying to understand what it actually does, you're in the right place. This combination antibiotic is commonly prescribed in India for infections of the gut, and while it's effective, it also comes with specific instructions that are worth understanding before you start your course.
In this guide, we'll walk through what O2 Tablet is, its uses, how it's typically dosed, possible side effects, who should be cautious with it, and what it usually costs. If your doctor has already written you a prescription, platforms like Nukkad Mall can help you find it at a nearby pharmacy and get it delivered without the hassle of running from store to store.
A quick note before we start: this article is for general information only. O2 Tablet is a prescription medicine, and dosage, duration, and suitability vary from person to person. Always follow your doctor's instructions rather than anything you read online, including this article.
O2 Tablet is a fixed-dose combination antibiotic used mainly to treat infections of the digestive tract that involve both bacteria and parasites at the same time.
O2 Tablet typically combines two active ingredients:
Because it pairs an antibiotic with an antiparasitic, this combination is designed for infections where more than one type of organism could be responsible for the symptoms — which is fairly common in gut infections.
The two ingredients attack infection-causing organisms in different ways. Ofloxacin interferes with an enzyme bacteria need to copy and repair their own DNA, which stops them from multiplying and eventually kills them. Ornidazole works on parasites and certain anaerobic bacteria by damaging their DNA directly, blocking their ability to grow and spread. Together, they're meant to cover a broader range of possible culprits than either ingredient would alone.
O2 Tablet is generally prescribed for mixed infections of the gastrointestinal tract. Doctors may recommend it for:
It's worth being clear about what O2 Tablet is not meant for. It isn't intended for viral illnesses like the common cold or flu, and it shouldn't be used for unrelated issues such as ordinary indigestion or IBS unless a doctor has specifically confirmed an infection that needs it.
| Condition | Can O2 Tablet Help? | Doctor Consultation Needed |
| Bacterial/infectious diarrhea | Often prescribed for this | Yes |
| Dysentery | Often prescribed for this | Yes |
| Mixed bacterial-parasitic gut infection | Often prescribed for this | Yes |
| Common cold or flu (viral) | No | Yes |
| IBS or general indigestion | IBS or general indigestion | Yes |
| Urinary tract infection | Urinary tract infection | Yes |
Dosage decisions for O2 Tablet should always come from your doctor, since they depend on the type and severity of infection, your age, weight, and overall health.
Doctors typically prescribe O2 Tablet as a short course, often once or twice daily, for a limited number of days depending on the infection being treated. There isn't a single "standard" dose that applies to everyone, which is exactly why self-prescribing based on something you've read online — including this article — isn't a good idea.
It's generally taken orally with a full glass of water, often with food to help with absorption and reduce stomach upset. The tablet should be swallowed whole rather than crushed or chewed unless your doctor tells you otherwise. Staying well hydrated is especially important if diarrhea is one of your symptoms.
If you forget a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed one rather than doubling up — taking two doses together isn't recommended.
Taking more than the prescribed amount doesn't work faster and can increase the risk of side effects. If you suspect an overdose or notice unusual symptoms after taking more than prescribed, contact a doctor or your nearest hospital right away rather than waiting to see how you feel.
Even if your symptoms improve after a couple of days, it's important to complete the full course your doctor prescribed. Stopping early is one of the most common reasons infections come back or become harder to treat later.
Like most antibiotics, O2 Tablet can cause side effects, though not everyone experiences them.
These are usually mild and tend to settle on their own:
If any of these persist, worsen, or bother you significantly, it's worth checking in with your doctor rather than just pushing through.
Less commonly, more serious reactions can occur. Seek medical attention promptly if you notice:
These reactions aren't common, but they're serious enough that they shouldn't be ignored if they happen.
O2 Tablet isn't suitable for everyone. Your doctor will usually want to know about the following before prescribing it:
If any of these apply to you, make sure your doctor is aware before you start the course.
A few practical precautions go a long way in avoiding complications:

The price of O2 Tablet can vary depending on the pharmacy, your city, the pack size, and whether you choose a branded version or a generic equivalent containing the same combination of ofloxacin and ornidazole. Generic alternatives are usually more affordable while containing the same active ingredients.
Since prices differ from one pharmacy to another, it's a good idea to compare before buying. Apps like Nukkad make this easier by connecting you with nearby pharmacies so you can check availability and pricing without having to call around or travel between stores.
O2 Tablet is a prescription medicine, so a valid prescription from a registered doctor is required to purchase it — genuine pharmacies, whether physical or online, will always ask for one.
Once you have a prescription, ordering through a trusted platform is often the most convenient route. Nukkad connects you with nearby local pharmacies so you can order prescribed medicines and get them delivered quickly, subject to stock availability at pharmacies near you. This is especially useful when you're unwell and would rather not step out to search multiple stores.
To keep O2 Tablet effective and safe:
O2 Tablet is a prescription antibiotic-antiparasitic combination commonly used for gut infections like infectious diarrhea and dysentery. It can be effective when taken correctly, but it also comes with precautions around dosage, alcohol use, and certain health conditions — which is exactly why it should only be taken under a doctor's guidance, never based on self-diagnosis.
If you've been prescribed O2 Tablet, make sure you understand the dosage and duration your doctor has recommended, watch for side effects, and complete the full course. When it's time to pick up your medicine, Nukkad can help you find it at a nearby pharmacy and get it delivered, subject to availability and prescription requirements.
1. What is the O2 Tablet used for?
O2 Tablet is a fixed-dose combination antibiotic that's mainly prescribed for mixed infections of the digestive tract, particularly ones where both bacteria and parasites may be responsible for the symptoms at the same time. It combines Ofloxacin, a fluoroquinolone antibiotic, with Ornidazole, a nitroimidazole antiparasitic and antibacterial agent, allowing it to cover a broader range of potential causes than either ingredient could handle alone. Doctors commonly prescribe it for conditions like infectious or bacterial diarrhea, dysentery, and certain intestinal infections caused by organisms such as Entamoeba or Giardia. It's worth being clear that this medicine isn't meant for viral illnesses like the common cold or flu, and it shouldn't be used for unrelated digestive issues like ordinary indigestion or IBS unless your doctor has specifically identified an infection that requires this particular combination.
2. What are the side effects of O2 Tablet?
Like most antibiotics, O2 Tablet can cause side effects, though the experience varies from person to person and not everyone will notice them. The more common ones tend to be mild and often settle on their own, including nausea, vomiting, stomach pain, headache, dizziness, and occasionally a metallic taste in the mouth. If any of these persist, worsen, or become genuinely bothersome, it's worth checking in with your doctor rather than just pushing through discomfort. Less commonly, more serious reactions can occur, and these need prompt medical attention — signs of an allergic reaction such as rash, swelling, or difficulty breathing, tendon pain or swelling, persistent or worsening diarrhea, yellowing of the skin or eyes, seizures, unusual confusion, numbness or tingling, and severe or persistent dizziness affecting your balance are all reactions that shouldn't be ignored if they happen during your course.
3. What is the recommended O2 Tablet dosage?
There isn't a single standard dosage that applies to everyone taking O2 Tablet, since the right amount depends on the specific type and severity of the infection being treated, along with your age, weight, and overall health condition. This is precisely why dosage decisions should always come directly from the prescribing doctor rather than from general information found online, including this article — what worked for someone else's infection, or even your own past prescription for a different illness, may not be appropriate for your current situation. Doctors typically prescribe it as a short course, often taken once or twice daily for a limited number of days depending on what's being treated. It's generally taken orally with a full glass of water, often alongside food to aid absorption and reduce stomach upset, and the tablet should be swallowed whole rather than crushed or chewed unless specifically instructed otherwise.
4. Can I take an O2 Tablet without food?
It's often recommended to take O2 Tablet with food, since this can help with absorption and reduce the likelihood of stomach discomfort that antibiotics sometimes cause on an empty stomach. That said, individual instructions can vary depending on your specific prescription and the doctor's assessment of your case, so it's important to follow whatever guidance your doctor has given you rather than assuming a general rule applies universally. If you've forgotten whether your prescription came with specific food-related instructions, it's worth checking directly with your doctor or pharmacist rather than guessing, particularly since consistency in how you take a course of antibiotics can matter for how effectively it works and how well your body tolerates it throughout the treatment period.
5. Is O2 Tablet safe during pregnancy?
O2 Tablet is generally avoided during pregnancy unless a doctor specifically determines that the benefit of treating the infection clearly outweighs the potential risk, since both fluoroquinolones and nitroimidazoles require particular caution in pregnant patients. This isn't a decision that should be made based on general information — it requires a doctor who's aware of the full clinical picture, including how far along the pregnancy is and the severity of the infection being treated, to weigh the risks and benefits appropriately. Similarly, breastfeeding mothers need medical guidance before taking this medicine, since it can pass into breast milk. Anyone who is pregnant, trying to conceive, or breastfeeding should make sure their doctor is fully aware of this before O2 Tablet is prescribed, so that either an alternative treatment or appropriate precautions can be considered.
6. Can I drink alcohol while taking O2 Tablet?
No, alcohol should be avoided entirely during the course of O2 Tablet treatment and for a few days after finishing it, since combining the two can lead to unpleasant reactions and worsen the medicine's side effects. This precaution is largely tied to how Ornidazole, one of the two active ingredients, interacts with alcohol in the body, and it's a widely recognised caution across nitroimidazole-based medications generally, not something unique to just this combination. Even a small amount of alcohol during treatment can increase the risk of symptoms like nausea, flushing, or a generally worse reaction than either the medicine or alcohol would cause on their own. Sticking to this precaution for the full duration of your course, plus the recommended buffer period afterward, is a simple but genuinely important way to avoid unnecessary complications.
7. Does O2 Tablet require a prescription?
Yes, O2 Tablet is strictly a prescription-only medicine, and it cannot legally be sold without a valid prescription from a registered doctor, whether you're buying it from a physical pharmacy or an online platform. This requirement exists because the medicine combines a fluoroquinolone antibiotic with a nitroimidazole antiparasitic, both of which need appropriate medical assessment to confirm they're the right treatment for your specific infection and that you don't have any contraindications, such as pregnancy, liver or kidney disease, a seizure history, or known allergies to related drug classes. Genuine pharmacies, including verified platforms like Nukkad, will always ask for a valid prescription before dispensing it, and this is actually a good sign of a trustworthy source — any seller willing to hand over a prescription antibiotic without one should be treated with caution.
8. How long does an O2 Tablet take to work?
Many people notice some improvement in their symptoms within a day or two of starting O2 Tablet, though the exact timeline can vary depending on the severity and specific nature of the infection being treated. What's genuinely important, regardless of how quickly symptoms start improving, is completing the full course exactly as your doctor prescribed it, rather than stopping early just because you're feeling better. Stopping an antibiotic course prematurely is one of the most common reasons infections come back or become harder to treat with the same medicine later, since surviving bacteria or parasites that weren't fully eliminated can develop resistance. Even if you feel completely back to normal after a couple of days, finishing the entire prescribed duration protects both your own recovery and reduces the broader risk of antibiotic resistance.
9. Can children take O2 Tablets?
O2 Tablet is generally not recommended for use in children, and it should only be considered if a pediatrician has specifically assessed the child's case and determined it's appropriate. This caution exists because both active ingredients in the combination — Ofloxacin and Ornidazole — carry considerations that are particularly relevant in younger patients, and fluoroquinolone antibiotics in general are typically used more cautiously in children compared to adults due to potential effects on developing bones and joints. If a child is showing symptoms of a gut infection, the right step is to consult a pediatrician who can properly evaluate the situation and recommend a treatment appropriate for the child's age, weight, and specific condition, rather than assuming an adult prescription or general information about this medicine applies to a child's case.
10. Where can I buy O2 Tablet online?
You can order O2 Tablet through a licensed online or local pharmacy, provided you have a valid prescription from a registered doctor, since it cannot legally be dispensed without one regardless of the platform. Once you have your prescription ready, Nukkad Mall makes the process considerably more convenient by connecting you with nearby local pharmacies, letting you check availability and compare pricing without having to physically visit or call multiple stores. Since pricing for O2 Tablet can vary depending on the pharmacy, your city, the pack size, and whether you choose a branded or generic version, being able to quickly compare options across nearby pharmacies through a single platform saves both time and potentially money. This is particularly useful when you're unwell and would genuinely rather not step out to search for your medicine in person, letting you get your prescribed course delivered instead.